8:00 am Morning Refreshments
8:25 am Chair’s Opening Remarks
MAKING IT A REALITY: SHOWCASING DIGITAL MEASURES FOR INTERVENTION ACROSS NEURODEGENERATION
8:30 am Exploring Digital Biomarker Research in Neurodegenerative Diseases
Synopsis
- Outlining studies and data from digital biomarkers research in Parkinson’s and Alzheimer’s Disease
- Utilizing data from acquired decentralized sources and clinical settings
- Developing digital biomarkers using multiple sensors targeting human activity and verbal communication.
9:00 am Advancing a Medical Device Technology to Slow Cognitive Decline and Modify Disease Progression in Alzheimer’s Disease
Synopsis
- Leveraging an innovative medical device technology to target participant function, cognition, and brain structure in Alzheimer’s Disease
- Launching our pivotal HOPE study in participants with mild-moderate Alzheimer’s Disease to demonstrate safety and efficacy
9:30 am Quantifying Digital Measures to Validate Digital Biomarkers for Parkinson’s Disorders
Synopsis
- Outlining strategy to develop digital measures to efficiently investigate Parkinson’s disease
- Objective measurement of task-based motor assessment using signal processing of wearable IMU data
- Evaluating digital measure clinical validity and sensitivity to disease progression
10:00 am Morning Break & Networking
10:30 am Panel Discussion: Leveraging Digital Biomarkers in Intervention & Drug Design Applications Across Different Neurological Indications
Synopsis
- Discussing the capabilities of digital biomarkers in disease intervention and drug design processes
- How do intervention applications differ across neurological indications?
- Evaluating product development strategy to achieve validation, approval, and commercial viability of digital intervention measures
11:00 am Roundtable Discussion: Dissecting Development of Digital Measures Across CNS Clinical Development
Synopsis
Join tables led by digital biomarker experts to discuss the benefits and challenges of different digital measures of neurological disorders.
- Debating a standardized measurement package to streamline biomarker validation
- Balancing device and assessment sensitivity and usability to maximize quality of collected data
EVALUATING DATA COLLECTION DEVICES TO OPTIMIZE PATIENT USABILITY & DATA QUALITY
11:30 am Utilizing Wearable Technologies for Digital Clinical Measures of Activity & Gait
Synopsis
- Evaluating wearable devices at different body locations to measure gait metrics
- Balancing different device and location’s measurement performance and usability to select the device best fit for purpose
- Exploring applications of digital measures to a wide range of indications
12:30 pm Lunch & Networking
1:30 pm Evaluating the Use of Wearable Technologies in Decentralized Clinical Trials & Applying Learnings to Ongoing Large Scale Studies
Synopsis
- Exploring results from recent studies utilizing wearable technologies in decentralized clinical trials
- Outlining the impact of disease severity on data collection
- Applying key learnings to the design of an ongoing large-scale cognitive trial
2:00 pm Considering Device Burden & Usability to Maximise Patient Compliance in Neurological Clinical Trials
Synopsis
- Identifying usability challenges and factors impacting device compliance
- Outlining strategies for minimizing usability challenges to reduce gaps in collected data
- Considerations regarding the use of less invasive data collection devices, e.g., non-wearable technologies
UTILIZING PATIENT CENTRIC CO-CREATION TO DESIGN CLINICALLY MEANINGFUL DIGITAL MEASURES
2:30 pm Exploring a Digital Cognitive Assessment to Incorporate into Routine Patient Care
Synopsis
- Utilizing digital measures to rapidly quantify cognitive ability
- Outlining the ability of digital tools for early care and intervention
- Undertaking a patient-centric approach to relate real-world ability and routine care
3:00 pm Establishing a Dialogue to Understand Priorities & Experiences from Clinical Trial Participation for Digital Measures
Synopsis
- What are the priorities that participants are looking to get out of clinical trials for digital measures?
- Reflecting on experiences from recent clinical trials – what additional burdens did recording digital measures cause or alleviate?
- How can digital measures further accommodate the patient perspective moving forward?
3:30 pm Chair’s Closing Remarks
3:45 pm End of Conference
